Can metastatic lymph node ratio (LNR) predict survival in oral cavity cancer patients?
| Autor: | Sanjay Talole, Anil K. D'Cruz, Sagar Vaishampayan, Shilpi Sharma, Jai Prakash Agarwal, Anuja Deshmukh, Suhail I. Sayed, Pankaj Chaturvedi, Devendra Chaukar, P. Rane |
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| Rok vydání: | 2013 |
| Předmět: |
Oncology
medicine.medical_specialty Multivariate analysis Receiver operating characteristic business.industry Proportional hazards model Hazard ratio Cancer General Medicine Oral cavity medicine.disease Confidence interval Surgery medicine.anatomical_structure Internal medicine medicine business Lymph node |
| Zdroj: | Journal of Surgical Oncology. 108:256-263 |
| ISSN: | 0022-4790 |
| Popis: | Objectives To evaluate the prognostic role of the lymph node ratio (LNR; ratio of total positive nodes to total dissected nodes) in oral squamous cell carcinoma (OSCC) as compared to pN staging with an aim to provide an optimal cut-off value. Methods 1,408 OSCC previously untreated patients who underwent treatment (surgery + neck dissection + adjuvant treatment). LNR sensitivity with respect to survival was calculated using receiver operating characteristic (ROC) curves and Cox regression method. LNR and TNM staging variables were subjected to multivariate analysis. Results LNR (0.088) showed significant association with survival outcomes. For patients with LNR ≤0.088, the OS, DFS, local control, regional control and distant metastasis rates were 64%, 70%, and 89%; for LNR >0.088 it was 22%, 19%, and 52%, respectively (P |
| Databáze: | OpenAIRE |
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