Prospective evaluation of the impact of human papilloma virus status and small node size on the diagnostic accuracy of 18F ‐fluorodeoxyglucose positron emission tomography/computed tomography for primary head and neck squamous cell carcinoma
| Autor: | Jonathan Lee, Louise Emmett, Bao Ho, Reuben Tang, Richard Gallagher, Peter Earls, Tim Matthews |
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| Rok vydání: | 2020 |
| Předmět: |
Human papilloma virus
business.industry Standardized uptake value General Medicine medicine.disease Head and neck squamous-cell carcinoma 03 medical and health sciences Dissection 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Node (computer science) Medicine 030211 gastroenterology & hepatology Surgery Lymph Tomography business Nuclear medicine Lymph node |
| Zdroj: | ANZ Journal of Surgery. 90:1396-1401 |
| ISSN: | 1445-2197 1445-1433 |
| Popis: | BACKGROUND Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) is well validated in the staging of pre-treatment head and neck squamous cell carcinoma (HNSCC), although the impact of human papilloma virus (HPV) status and node size on accuracy remains unclear. The aim of this study was to assess the diagnostic accuracy of PET/CT based on HPV status and node size and determine the effects of maximum standardized uptake value thresholds on sensitivity, specificity and positive predictive value. METHODS A total of 38 patients with primary HNSCC were recruited. All patients underwent primary tumour resection and cervical node dissection following FDG-PET/CT. RESULTS A total of 38 patients including 68 dissected necks, representing 353 nodal levels and a total of 2701 lymph nodes were included. Histopathological analysis revealed lymph node metastases in 4.3% (116/2701) of dissected lymph nodes. Forty-four percent of patients had HPV-positive tumours. Sixty-four percent of involved lymph nodes were |
| Databáze: | OpenAIRE |
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