Elastin hydrolysate derived from fish enhances proliferation of human skin fibroblasts and elastin synthesis in human skin fibroblasts and improves the skin conditions
| Autor: | Misako Nakaba, Eri Shiratsuchi, Michio Yamada |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Human skin macromolecular substances Placebo group Hydrolysate 03 medical and health sciences Internal medicine medicine Ingestion Beneficial effects Nutrition and Dietetics integumentary system biology Chemistry Cell growth 030104 developmental biology Endocrinology Biochemistry cardiovascular system biology.protein Agronomy and Crop Science Elastin Food Science Biotechnology Skin elasticity |
| Zdroj: | Journal of the Science of Food and Agriculture. 96:1672-1677 |
| ISSN: | 0022-5142 |
| DOI: | 10.1002/jsfa.7270 |
| Popis: | BACKGROUND Recent studies have shown that certain peptides significantly improve skin conditions, such as skin elasticity and the moisture content of the skin of healthy woman. This study aimed to investigate the effects of elastin hydrolysate on human skin. Proliferation and elastin synthesis were evaluated in human skin fibroblasts exposed to elastin hydrolysate and proryl-glycine (Pro-Gly), which is present in human blood after elastin hydrolysate ingestion. We also performed an ingestion test with elastin hydrolysate in humans and evaluated skin condition. RESULTS Elastin hydrolysate and Pro-Gly enhanced the proliferation of fibroblasts and elastin synthesis. Maximal proliferation response was observed at 25 ng mL−1 Pro-Gly. Ingestion of elastin hydrolysate improved skin condition, such as elasticity, number of wrinkles, and blood flow. Elasticity improved by 4% in the elastin hydrolysate group compared with 2% in the placebo group. CONCLUSION Therefore, elastin hydrolysate activates human skin fibroblasts and has beneficial effects on skin conditions. © 2015 Society of Chemical Industry |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text