Identification of a series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with activity on PPARα, PPARγ, and PPARδ
| Autor: | Andrea H. Ayscue, Daniel D. Sternbach, Millard H. Lambert, Jennifer S. Smith, Timothy M. Willson, Brad R. Henke, Kelli D. Plunket, Kevin G. Liu, Lisa M. Leesnitzer |
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| Rok vydání: | 2001 |
| Předmět: |
Agonist
chemistry.chemical_classification medicine.drug_class Stereochemistry Carboxylic acid Organic Chemistry Clinical Biochemistry Pharmaceutical Science Oxadiazole Ether Biochemistry Chemical synthesis Partial agonist In vitro chemistry.chemical_compound chemistry Drug Discovery medicine Molecular Medicine Enantiomer Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 11:2385-2388 |
| ISSN: | 0960-894X |
| Popis: | A series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with dual agonist activity on PPARα and PPARγ is described. Several of these compounds also showed partial agonist activity on PPARδ. Resolution of one analogue showed that PPARα and PPARγ activity resided in mainly one enantiomer, whereas PPARδ activity was retained in both enantiomers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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