Antitumor and toxic properties of liposomes containing cis-dichlorodiaminoplatinum

Autor:	Lev D. Bergelson, Yu. Sh. Moshkovskii, G. I. Muzya, Gor'kova Np, L. A. Piruzyan, L. I. Barsukov, Sorokina Ib
Rok vydání:	1981
Předmět:	Antitumor activity Liposome chemistry.chemical_element General Medicine Limiting Principal factor General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Biochemistry chemistry Toxicity Distribution (pharmacology) Platinum DNA
Zdroj:	Bulletin of Experimental Biology and Medicine. 92:1550-1552
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00829901
Popis:	Several complex compounds of platinum, including cis-dichlorodiaminoplatinum (CDP), possess marked antitumor activity, probably due to their interaction with DNA [3, 4, 91. However, the practical application of platinum complexes is made difficult by their high toxicity; the principal factor limiting the use of effective doses of the compound is a disturbance of renal function [9]. It was shown recently [ 111 that the distribution of therapeutic substances in the organs and tissues of a recipient can be modified by incorporating them into phospholipid vesicles or liposomes.
Databáze:	OpenAIRE
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