l-Tryptophan Schiff base cadmium(II) complexes as a new class of proteasome inhibitors and apoptosis inducers in human breast cancer cells
| Autor: | Nan Zhang, Daniela Buac, Xia Zhang, Zhen Zhang, Yuhua Fan, Yanfei Ma, Q. Ping Dou, Caifeng Bi, Gui-Mei Huang, Xin-ping Wang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cadmium Schiff base Stereochemistry Tryptophan chemistry.chemical_element Inorganic Chemistry 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry Proteasome Apoptosis 030220 oncology & carcinogenesis Cancer cell Materials Chemistry Proteasome inhibitor medicine Physical and Theoretical Chemistry Carcinogen medicine.drug |
| Zdroj: | Inorganica Chimica Acta. 466:478-485 |
| ISSN: | 0020-1693 |
| Popis: | Although cadmium is a widespread environmental contaminant and human carcinogen, our studies indicate an organic cadmium complex to be a potent inhibitor of proteasomal chymotrypsin-like (CT-like) activity, further capable of inducing apoptosis in a cancer cell-specific manner. Many clinical studies suggest the use of proteasome inhibitors as potential novel anticancer agents and in the present study, we have synthesized three novel l -tryptophan-containing cadmium complexes: Cd(C 17 H 15 N 4 O 2 ) 2 ·2CH 3 OH ( 1 ) (C 17 H 15 N 4 O 2 = 2-acetylpyrazine- l -tryptophan), Cd(C 17 H 15 N 2 O 3 ) 2 ·2CH 3 OH ( 2 ) (C 17 H 15 N 2 O 3 = 5-methylfurfural- l -tryptophan) and Cd(C 16 H 12 N 2 O 2 SBr) 2 ·2CH 3 OH ( 3 ) (C 16 H 12 N 2 O 2 SBr = 5-bromo-2-thiophenecarbaldehyde- l -tryptophan) and found that under comparable conditions cadmium complexes 1 and 2 , but not 3 , have proteasome-inhibitory activity in human breast cancer MDA-MB-231 cells. Our results suggest that l -tryptophan Schiff base cadmium complexes are potent proteasome inhibitors. |
| Databáze: | OpenAIRE |
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