Adipose-Derived Stem Cells: In Musculoskeletal Disorders

Autor: Dhanasekaran Marappagounder, Padmanav Behera, Ravikumar Rajappa, Sandeep Kumar Kotturu, Rajanna Ajumeera
Rok vydání: 2014
Předmět:
Zdroj: Stem Cell Therapy for Organ Failure ISBN: 9788132221098
Popis: Conceptually and from a practical standpoint, bone marrow has been the most influential source of stem cells that offers a possibility of being used in a wide range of therapeutics. Clinical situations frequently demand stem cells with dependable quality and quantity to treat disorders of cellular degeneration. Challenges to bring advances to the clinical mount have expanded rapidly, engendering new perspectives concerning the identity, origin, and full therapeutic potential of various tissue-specific stem cells. Recent progress in stem cell biology has allowed researchers to investigate distinct stem cell populations in such divergent mammalian tissues and organs. Taking stem cells adaptable for regenerative medicine applications in adequate quantities at the right time is a challenge. In this respect, an emerging body of literature suggests that redundant adipose tissue serves as an abundant, accessible, and reliable source of stem cells that can be readily harvested with minimal risk to the patients. Rapidly accumulating evidence suggests that adipose tissue-derived stem cells (ADSC), especially from white adipose tissue, possess a far wider property of self-renewal and multilineage differentiation capacity, thereby highlighting their importance and effectiveness in regenerative medicine [1–5]. Despite literature supporting the capacity and plasticity of ADSC for regenerative medicine, there are functional and heterogeneous discrepancies associated with it, thus presenting ADSC research a difficult and challenging task. Promising strides are continuously being made to unravel these challenges and realize the potential of ADSC. While much progress on adipose-derived stem cells has been made in the last few years, there remain a lot to be explored.
Databáze: OpenAIRE