Acute Phase Proteins: Journey of Pivotal Marker in Periodontal Disease

Autor:	Mukesh Ardale, Vishnudas Dwarkadas Bhandari, Surbhi Khaparde, Rashmi Jawade, Kailash Mundada, Gauri Ugale
Rok vydání:	2016
Předmět:	business.industry Acute-phase protein Inflammation 030206 dentistry Systemic inflammation Blood proteins 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Periodontal disease Plasma concentration Immunology Medicine Tumor necrosis factor alpha medicine.symptom business
Zdroj:	IOSR Journal of Dental and Medical Sciences. 15:92-99
ISSN:	2279-0853 2279-0861
DOI:	10.9790/0853-150779299
Popis:	Periodontal disease is a chronic and concealed infection. It has become progressively clearer in recent years that periodontal disease can cause remarkable increase as well as decrease in the levels of markers of systemic inflammation. These markers include chiefly plasma proteins such as acute phase proteins. The acute phase proteins are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation. Acute phase proteins are generated in the host by a process called as acute phase reaction which is mediated by cytokines like Interleukin-1, 6, 8 and tumor necrosis factorα. The rise in the plasma concentration of acute phase proteins can assist host defense by aiding recognition of invading microbes, mobilization of leukocytes into the circulation, and increasing blood flow to injured or infected sites. This review reiterates on the structure, synthesis, classification, functions of acute phase proteins and their interrelationship with periodontal disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cfec6d1b81e9846238dd35dd9ba7d7ba https://doi.org/10.9790/0853-150779299 Zobrazit plný text záznamu