Evaluation of alpha-fetoprotein in detecting hepatocellular carcinoma recurrence after radiofrequency ablation
| Autor: | Myron J. Tong, David S.K. Lu, Surachate Siripongsakun, Stephanie Lin, Sindy H Wei, Jeffrey L. Chen, Steven S. Raman, James Sayre |
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| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty Hepatology Radiofrequency ablation business.industry digestive oral and skin physiology Gastroenterology medicine.disease Cancer recurrence digestive system diseases law.invention True negative law Hepatocellular carcinoma Internal medicine Concomitant embryonic structures medicine False positive rate Alanine aminotransferase Alpha-fetoprotein business neoplasms |
| Zdroj: | Journal of Gastroenterology and Hepatology. 29:157-164 |
| ISSN: | 0815-9319 |
| DOI: | 10.1111/jgh.12438 |
| Popis: | Background and Aim The performance of alpha-fetoprotein (AFP) in the detection of hepatocellular carcinoma (HCC) recurrence after radiofrequency ablation was analyzed. Methods One hundred and forty-six solitary HCC lesions treated by radiofrequency ablation were evaluated. Using the AFP cutoff level at ≥ 20 ng/mL, tumors were categorized into AFP or non-AFP-producing HCC. Factors associated with true and false interpretations for cancer recurrence including analysis of elevated alanine aminotransferase (ALT) were evaluated. The performance of AFP using different cutoff levels adjusted for abnormal ALT was compared. Results Of 146 HCCs, 103 demonstrated no HCC recurrence while 43 had local recurrence. In non-recurrence HCC cases, increased AFP levels (false positive) were associated with concomitant ALT elevations, while those with normal AFP (true negative) had correspondingly normal ALT values (P |
| Databáze: | OpenAIRE |
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