Association between T-182C polymorphism of the norepinephrine transporter SLC6A2(NET) gene and major depressive disorder in Iraqi patients
| Autor: | Wisam Abed Al-Amer Rady, Kareem Nasir Hussein, Ali Hmood Al. Saadi |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | International journal of health sciences. :6426-6433 |
| ISSN: | 2550-696X 2550-6978 |
| DOI: | 10.53730/ijhs.v6ns4.9619 |
| Popis: | Major sympathetic nervous system neurotransmitter that is responsible for consciousness, attention, cognitive ability, as well as the function of the majority of body systems, glands, and the immune system, is called Norepinephrine (NE). Norepinephrine transporter (NET) and norepinephrine binding sites are decreased in the brains of MDD patients, showing that dysregulated synaptic NE plays a role in the pathophysiology of MDD. Indeed, different NET polymorphism combinations may be linked to different MDD sub-phenotypes. The aim of the current work is to investigate or detect if there is a relation between T-182C gene polymorphism of SLC6A2 gene with major depressive disorder (MDD) in Iraqi patients.Materials and Methods: Blood specimens were collected from 70 individuals with MDD and 20 healthy individuals as a control group (both patients and control ages ranged between 18-65 years). DNA extracted from white blood cells (WBC), and the T-182C gene was detected and amplified by the PCR-ARMS technique. Results: The distribution of TT, TC, and CC genotype ratio of MDD group was 22.9%, 27.1%, and 50.0%, respectively. While the control group show genotype distribution as 35.0% for TT, 55.0% for TC and 10.0% for CC ratio. |
| Databáze: | OpenAIRE |
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