Emulsion electrospun polylactic acid/Apocynum venetum nanocellulose nanofiber membranes with controlled sea buckthorn extract release as a drug delivery system
| Autor: | Ying Wang, Qingle Zhang, Ling Wang, Lu Wang, Xin Xia, Chenmeizi Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Polymers and Plastics
ved/biology ved/biology.organism_classification_rank.species 02 engineering and technology Drug action Pharmacology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Nanocellulose chemistry.chemical_compound Polylactic acid chemistry Nanofiber Toxicity Drug delivery Emulsion Chemical Engineering (miscellaneous) Apocynum venetum 0210 nano-technology |
| Zdroj: | Textile Research Journal. 91:1046-1055 |
| ISSN: | 1746-7748 0040-5175 |
| DOI: | 10.1177/0040517520970171 |
| Popis: | Prolonging the duration of drug action and reducing toxicity play a vital role in wound administration as they reduce the chance of infection and decrease complications and cost. This study reports the natural antioxidant procyanidins extracted from sea buckthorn (SBT) and laboratory-manufactured Apocynum venetum cellulose nanofiber as core drugs. The sustained-release nanofiber membrane was prepared by electrospinning on polylactic acid/polyvinyl pyrrolidone nanofibers. High-performance liquid chromatography-mass spectrometry was used to identify the phenolic compounds in SBT extracts and confirmed the presence of procyanidins with a content of 0.0345 mg/g. The nanofiber membrane was characterized through transmission electron microscopy, encapsulation efficiency, in vitro drug-release study and antioxidant assay. The results indicated that the extracted procyanidins were successfully encapsulated in the core–sheath structure nanofibers, and the encapsulation efficiency of nanofiber membranes reached 83.84%. In vitro measurements of the delivery showed this core–sheath structure could significantly alleviate the drug burst release, which is followed by a linear and smooth release within 30 hours. Further tests showed that the removal efficiency of 2,2-diphenyl-1-picrylhydrazyl reached 88.62%, indicating that the membranes had high antioxidant activity. This work implies that the combination of Apocynum venetum nanocellulose and emulsion electrospun fibers has promising potential applications in tissue engineering or drug delivery. |
| Databáze: | OpenAIRE |
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