Ekspresja wybranych receptorów chemokin na limfocytach Th przerosłych migdałków gardłowych w wysiękowym zapaleniu ucha środkowego
| Autor: | Edwina Kasprzycka, Jolanta Wysocka, Beata Żelazowska-Rutkowska, Karol Ratomski, Bożena Skotnicka, Janusz Żak, Elżbieta Hassmann-Poznańska |
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| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test business.industry CCR3 CCR4 Adenoid Flow cytometry stomatognathic diseases Chemokine receptor Otitis medicine.anatomical_structure Otorhinolaryngology Effusion Immunology otorhinolaryngologic diseases medicine medicine.symptom business Receptor |
| Zdroj: | Otolaryngologia Polska. 63:131-135 |
| ISSN: | 0030-6657 |
| DOI: | 10.1016/s0030-6657(09)70093-9 |
| Popis: | Summary Introduction Chemokine receptors play a crucial role in the recruitment of leucocytes into inflamed tissue from secondary lymphoid organs. Aim of this study was evaluation of the percentage Th (CD4+) lymphocytes with expression of chemokine receptors: CCR3, CCR4, and CCR5 in hypertrophied adenois tissue in children with otitis media with effusion. Material and methods 36 children with otitis media with effusion and 25 children with hypertrophied adenoids were tested. Expression of chemokine receptors CCR3, CCR4 and CCR5 on T CD4 lymphocytes of hypertrophied adenoid's tissue was estimated by flow cytometry method. Results Average percentage of T CD4+ lymphocytes with expression CCR4 in hypertrophied adenoid in children group with otitis media with effusion (OME = 64,11%) was significantly higher than in comparative group with hypertrophied adenoid (HA = 75,05%, p Conclusion Results suggests that intensify of humoral immunological answer in hypertrophied adenoid depends on Th2 lymphocytes with expression CCR3 and CCR4 chemokine receptors in course of inflammatory state in middle ear. |
| Databáze: | OpenAIRE |
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