Adsorption of Zwitterionic Drugs on Oxidized Cellulose from Aqueous and Water/Alcohol Solutions

Autor:	Pavel M. Bychkovsky, Dmitry S. Zimnitsky, T. L. Yurkshtovich
Rok vydání:	2004
Předmět:	Aqueous solution Chemistry Oxidized cellulose Ionic bonding Alcohol Surfaces Coatings and Films chemistry.chemical_compound Crystallinity Adsorption Zwitterion Materials Chemistry Organic chemistry Molecule Physical and Theoretical Chemistry
Zdroj:	The Journal of Physical Chemistry B. 108:17812-17817
ISSN:	1520-5207 1520-6106
DOI:	10.1021/jp0472010
Popis:	Adsorption of zwitterionic drugs (β-lactam antibiotics and amino acids) on samples of oxidized cellulose (OC) with various carboxyl contents and structure characteristics was investigated from aqueous and water/alcohol solutions. The process is described according to the theory of localized stoichiometric adsorption and represented by Langmuir-like isotherms. The drug uptake increases with increase of alcohol content in the solution and with growth of alcohol molecular weight. The main contribution to the increase of drug uptake with addition of alcohol to the aqueous drug solution is provided by the desolvation of zwitterion ionic groups, which increases with growth of alcohol content. The structural characteristics of OC (degree of crystallinity and carboxyls distribution) and sorbate molecule size have considerable effect on the drug adsorption. It is shown that different drug uptake occurs on the OC samples with similar exchange capacity but various structure characteristics, which can be explained by...
Databáze:	OpenAIRE
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