| Autor: |
L. Tarditi, Marta Cremonesi, C. Meares, R. Franceschini, Chiara Maria Grana, Marco Chinol, Antonio G. Siccardi, A. Pecorale, A. Corti, Giovanni Paganelli, M. Fiorenza |
| Rok vydání: |
1997 |
| Předmět: |
|
| Zdroj: |
Radioactive Isotopes in Clinical Medicine and Research ISBN: 9783034877749 |
| DOI: |
10.1007/978-3-0348-7772-5_86 |
| Popis: |
Three-step monoclonal antibody tumor targeting using the avidin-biotin system has been successfully applied to the detection of a variety of solid tumors. We have adopted the same protocol in a pilot therapy trial introducing the therapeutic radionuclide yttrium-90 (Y-90). Eleven patients with various tumors were administered with Y-90 doses ranging from 1.85 to 5.55 GBq. Treatment was well tolerated and no acute toxicity was observed. One patient with brain tumor achieved over 50% regression while another showed a total regression of one of his metastases. Overall 4 out of 11 pts are still in partial remission 1–5 months after therapy. The work is still in progress, however, these preliminary data are encouraging and warrant further studies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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