Synthesis of the orally active spiroindoline-based growth hormone secretagogue, MK-677

Autor:	Kai Rossen, Ralph P. Volante, David Askin, Robert A. Reamer, Joseph E. Lynch, Veena Upadhyay, Paul J. Reider, Kenneth M. Wells, Ioannis N. Houpis, Jess Sager, Peter G. Houghton, Audrey Molina, Peter E. Maligres
Rok vydání:	1997
Předmět:	Indole test chemistry.chemical_compound Orally active chemistry Growth hormone secretagogue Stereochemistry Organic Chemistry Drug Discovery Isonipecotic acid Biochemistry
Zdroj:	Tetrahedron. 53:10983-10992
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(97)00359-1
Popis:	The preparation of the Merck Growth Hormone Secretagogue; MK-677 is described. A Fischer indole/reduction based strategy provides the novel spiroindoline nucleus of this potent compound. This optimized sequence necessitates the isolation of only one intermediate 10 and provides MK-677 in 48% overall yield from isonipecotic acid 3.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cfac074b94c92a0e3e4c371fdd2accb3 https://doi.org/10.1016/s0040-4020(97)00359-1 Zobrazit plný text záznamu Full Text from ScienceDirect