EXPERIMENTAL EVALUATION OF AQUEOUS HUMOUR LOW-MOLECULAR PROTEINS DEGRADATION DUE TO COMBINED CORNEAL, IRIDIAL AND LENS PENETRATING EYE INJURY: THE INFLUENCE OF PROSTAGLANDINS AND THEIR SYNTHESIS INHIBITORS

Autor:	Ya I Penishkevych, O. P. Kuchuk, V I Ushakov
Rok vydání:	2017
Předmět:	Lysis genetic structures Aqueous humour Chemistry General Engineering Pharmacology medicine.disease eye diseases Ciliary body medicine.anatomical_structure Diclofenac Fibrosis Lens (anatomy) medicine sense organs Iris (anatomy) Dexamethasone medicine.drug
Zdroj:	Clinical anatomy and operative surgery. 16:38-41
ISSN:	1993-5897 1727-0847
Popis:	The task of the study was to evaluate the effect of prostaglandins and their synthesis inhibitors on proteolytic activity of rabbit aqueous humour due to combined corneal, iridial and lens penetrating eye injury. 40 eyes of 40 Shinshilla rabbits were treated. The intensity of low-molecular proteins lysis due to penetrating ciliary body injury does not change, while collagen activity of aqueous humour increases throughout all period of the experiment. PGЕ1 and PG F2α are determined to reduce degradation degree of low-molecular proteins, PG Е2 increases the intensity of asocasein lysis, therefore decreasing intensity of proteolytic collagen disintegration (cleavage). Paracetamol, diclofenac and dexamethasone decrease the proteolylysis of low-molecular proteins, but essentially raise collagenalytic activity of anterior chamber aqueous humour of rabbit eyes due to combined corneal, iris and lens penetrating injury. Differential choice of used drugs prevents excessive fibrosis of the ocular tissues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cfab77b72bcafe1a50133c331590da6e https://doi.org/10.24061/1727-0847.16.1.2017.8 Zobrazit plný text záznamu