Kidney-on-a-Chip
| Autor: | Martijn J. Wilmer, Jelle Vriend, Rosalinde Masereeuw |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Kidney repair Nephrology medicine.medical_specialty Kidney Continuous flow medicine.medical_treatment 02 engineering and technology Pharmacology Biology 021001 nanoscience & nanotechnology Bioinformatics medicine.disease Efficacy Transplantation 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Internal medicine medicine 0210 nano-technology Dialysis Kidney disease |
| DOI: | 10.1016/b978-0-12-801734-0.00082-5 |
| Popis: | Chronic kidney disease (CKD) is a global health problem with significant morbidity and mortality. Currently, the only two therapeutic options offered to patients are dialysis and renal transplantation, but each with significant limitations. There is a critical need for improved model systems to study renal tissue repair or predict drug efficacy and safety. Recent advances in tissue culture systems acknowledge the importance of the tissue microenvironment in optimal functioning and responsiveness. Communication between cells is essential as well as biomechanic and chemotactic processes, which influence cell proliferation, migration, and differentiation processes. These processes are advanced when tissues are cultured in 3D-platforms and under continuous flow conditions. This chapter gives an overview of innovative technologies related to 3D kidney cell cultures. Examples of three technologies (hollow fiber membranes, gel-based systems, and microfluidics) will be discussed with respect to their suitability in studying pharmacological and therapeutic approaches in regenerative nephrology. |
| Databáze: | OpenAIRE |
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