ChemInform Abstract: Synthesis of 1,3,4-Oxadiazol-2-ones with Aliphatic Groups at N-3

Autor: Michael D. Graves, Brenda F. Johnson, Dianne D. Singleton, Jamin Huang, Dean F. Bushey
Rok vydání: 1987
Předmět:
Zdroj: ChemInform. 18
ISSN: 0931-7597
DOI: 10.1002/chin.198741219
Popis: A series of 3-substituted-5-methoxy-1,3,4-oxadiazol-2-ones were prepared from aldehydes, ketones, phenylacetic acids, and 1,2- and 1,3-diketones. Conditions for the formation of these oxadiazolones from the precursor N-carbamoyl chlorides depended on the structure, and varied from spontaneous ring closure to those requiring bases. Variation in the N-3 substituents sometimes produced mixtures of isomers which were separated and identified. These molecules were prepared in order to study the effect of the N-3 substituent variation on the biological properties of oxadiazolones.
Databáze: OpenAIRE