The microvasculature of invasive ductal breast carcinoma: a sterological approach
| Autor: | Grace Callagy, Michael J. Kerin, Catherine Curran, Peter Dockery, Sarah Mahon, Nicola Miller |
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| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Cancer Research. 69:1057 |
| ISSN: | 1538-7445 0008-5472 |
| Popis: | Abstract #1057 Background: Microvessel density (MVD) is a commonly used parameter to describe tumour vascularity and has been widely studied as a possible prognosticator in breast cancer. Other descriptors of vascular beds have been developed and have been applied to a variety of systems including the reproductive and nervous systems. These stereological approaches are providing objective unbiased assessment of various vascular beds. Aim: The aim of this pilot study was to use stereological methods to describe the vasculature in invasive ductal breast carcinoma, to test the hypothesis that microvasculature anatomy effects Tumor Grade, Size and Nodal Status. Methods: A cohort of 51 breast cancer patients with pre-menopausal invasive ductal carcinoma and moderate NPI was identified.Sections were stained with CD34 using the automated Ventana Discovery staining platform. A number of stereological parameters were estimated in three tissue compartments (gland,stroma and adipose):Number per Unit area (Na), Length Density (Lv) and Radial Diffusion Distance. Data was analysed using Analyses of Variance methods using Minitab© Statistical software. Results: There was no significant difference in the radial diffusion difference when groups were analysed by Grade Size and Nodal Status. Similar results were found for Na and Lv Conclusion: This study suggests that there is no simple link between tumor vasculature and Grade, size and nodal status in Invasive Ductal Breast Carcinoma. This study illustrates the potential usefulness of the stereological approach in the study of vascular beds in breast cancer studies by providing access to potentially physiologically relevant anatomical parameters of microvasculature beds. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 1057. |
| Databáze: | OpenAIRE |
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