Effect of water-Insoluble Powder Addition on Physical Properties of Gelatin Gel
| Autor: | Shigemitsu Osawa, Yoshiteru Kato, Kazuhisa Samura, Yutaka Morita, Noritoshi Koyama, Masao Kawamura |
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| Rok vydání: | 1993 |
| Předmět: |
Pharmacology
Materials science food.ingredient Organic Chemistry Pharmaceutical Science Young's modulus Gelatin Dosage form Titanium oxide law.invention chemistry.chemical_compound symbols.namesake food Calcium carbonate chemistry Magazine law Drug Discovery Ultimate tensile strength symbols Composite material Tensile testing |
| Zdroj: | Drug Development and Industrial Pharmacy. 19:2579-2594 |
| ISSN: | 1520-5762 0363-9045 |
| DOI: | 10.3109/03639049309047202 |
| Popis: | Water-insoluble powder is often dispersed in shells of commercial soft capsules for various reasons, but little reports have been published about the effect of powder addition on the physical properties of the gelatin gel. Glass powder, titanium oxide, calcium carbonate and γ-orizanol were used as model of powder. Changes of Young modulus obtained from the tensile test showed that any powder addition to the gelatin sheet made the gelatin sheet hard not by the surface effect of powder but by the volumetric effect of it. In this test, any powders had no effect on the tensile strength of the gelatin sheet because there was little interaction between each powder and the gelatin gel in the break point. The limiting strain was decreased a little up to the specific amount of each powder and then beyond the specific amount that decreased steeply in the case of glass powder and γ-orizanol. There might be a suitable range of the amount of powder for the gelatin sheet to keep the plastic flow similar to the ... |
| Databáze: | OpenAIRE |
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