Biomimetic synthetic studies on lactonamycin: an expedient synthesis of dihydroxy-isoindolinone-carboxylates

Autor:	Bhavesh H. Patel, Sylvain A. Jacques, Anthony G. M. Barrett
Rok vydání:	2011
Předmět:	Lactonamycin chemistry.chemical_compound Sarcosine Chemistry Organic Chemistry Drug Discovery Aromatization Moiety Organic chemistry Biochemistry
Zdroj:	Tetrahedron Letters. 52:6072-6075
ISSN:	0040-4039
Popis:	The synthesis of dihydroxy-isoindolinone-carboxylates from a dioxinone keto-ester and N-protected sarcosine without the use of phenolic protection is described. Base-induced aromatization of the dioxinone diketo-ester followed by lactamization furnished the desired dihydroxy-isoindolinone moiety, which could be used as an EF-ring precursor toward the synthesis of lactonamycin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cf9ea73438536392e55f4b70a13e2a15 https://doi.org/10.1016/j.tetlet.2011.08.173 Zobrazit plný text záznamu Full Text from ScienceDirect