FT-Raman and FT-IR studies of 1:2.5 piroxicam: β-cyclodextrin inclusion compound
| Autor: | Margherita Zanol, Enrico Redenti, Paolo Ventura, Paola Taddei, Alessandro Bertoluzza, Mauro Rossi |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
chemistry.chemical_classification
Cyclodextrin Chemistry Hydrogen bond Organic Chemistry Piroxicam Analytical Chemistry Inclusion compound Inorganic Chemistry Crystallography chemistry.chemical_compound Polymorphism (materials science) medicine Fourier transform infrared spectroscopy Solubility Dissolution Spectroscopy medicine.drug |
| Zdroj: | Journal of Molecular Structure. :535-539 |
| ISSN: | 0022-2860 |
| DOI: | 10.1016/s0022-2860(98)00734-0 |
| Popis: | The FT-Raman and FT-IR spectra of amorphous 1:2.5 piroxicam (P): β-cyclodextrin (βCD) inclusion compound (PβCD) are presented and discussed in comparison with the spectra of the three main modifications of piroxicam (α,β and monohydrate). In the 1700–1200 cm −1 FT-Raman spectrum of 1:2.5 PβCD inclusion compound the bands of βCD are weak and covered by those stronger of piroxicam, differently from the FT-IR spectrum where the bands of βCD are stronger, so covering a large part of the spectrum. Typical FT-Raman marker bands are assigned for the characterization of the three modifications of piroxicam. The FT-Raman spectrum of 1:2.5 PβCD inclusion compound predominantly shows the bands at about 1465 and 1400 cm −1 of the monohydrate, indicating that piroxicam assumes the zwitterionic structure stabilized by interaction with βCD via electrostatic and hydrogen bonds. The dipolar character of 1:2.5 PβCD inclusion compound improves the solubility and the dissolution rate of piroxicam and thus its rate of absorption. |
| Databáze: | OpenAIRE |
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