Stereocontrolled Synthesis of Delgocitinib, a JAK Inhibitor for the Treatment of Atopic Dermatitis

Autor:	Takiguchi Hiromu, Takeichi Tsubasa, Takashi Inaba, Takashi Watanabe, Takahisa Shimazaki, Akinobu Higashi
Rok vydání:	2021
Předmět:	body regions 010405 organic chemistry Chemistry Organic Chemistry Cancer research medicine Atopic dermatitis Physical and Theoretical Chemistry 010402 general chemistry medicine.disease 01 natural sciences 0104 chemical sciences Janus kinase inhibitor
Zdroj:	Organic Process Research & Development. 25:342-348
ISSN:	1520-586X 1083-6160
DOI:	10.1021/acs.oprd.1c00031
Popis:	Herein is reported the nine-step commercial synthesis of delgocitinib, a Janus kinase inhibitor approved for the treatment of atopic dermatitis in 2020. Its chiral spirodiamine core was selectively...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cf966a4fbc3e941d3c234daa3a06e9e8 https://doi.org/10.1021/acs.oprd.1c00031 Zobrazit plný text záznamu