Synthesis of 2-[3′-(trifluoromethyl)anilino] -5-hydroxynicotinic acid

Autor:	Josef Němec, Eric C. Schreiber, Fred S. Meeker
Rok vydání:	1974
Předmět:	Hydroxylation chemistry.chemical_compound Trifluoromethyl chemistry Stereochemistry Organic Chemistry Sequence (medicine)
Zdroj:	Journal of Heterocyclic Chemistry. 11:569-573
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570110422
Popis:	2-[3′-(Trifluoromethyl)anilino]-5-hydroxynicotinic acid (2) was synthesized by two routes: a) by direct hydroxylation of 2-[3′-(trifluoromethyl)anilino]nicotinie acid (1); and b) by the following sequence starting from 2-chloro-3-methyl-5-nitropyridine (3) via 5-amino-2-chloro-3-methylpyridine (4), 2-ehloro-5-hydroxy-3-methylpyridine (6), 5-acetoxy-2-chloro-3-methylpyridine (7), 5-acetoxy-2-chloronicotinie acid (8), and 2-chloro-5-hydroxynicotinic acid (9). The correlation of 2 with one of the metabolites of 1 has been accomplished, and the identities of both compounds have been proven.
Databáze:	OpenAIRE
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