Changes in thyroid economy induced by carbamazepine(CBZ) therapy in L-T4 substituted hepothyroid children
| Autor: | F Triharchi, A. Sindoni, G Maiouno, H Scaffidi, F. De Luca |
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| Rok vydání: | 1984 |
| Předmět: |
Diminution
endocrine system medicine.medical_specialty endocrine system diseases business.industry Thyroid Stimulation Carbamazepine Pharmacology Blood proteins Titer Endocrinology medicine.anatomical_structure Internal medicine Pediatrics Perinatology and Child Health medicine Microsome business medicine.drug Hormone |
| Zdroj: | Pediatric Research. 18:1223-1223 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-198411000-00132 |
| Popis: | CBZ treatment is known to decrease serum thyroid hormone titers, without generally affecting TSH levels or the thyroid status. The mechanism for this transiente effect has been not yet defined. In 5 L-T4 substituted hypothyroid children with partial epilepsy serum T4 (μg/dl), FT4 (pg/ml) and rT3 (ng/dl) significantly decreased (table) after (B) 2-mth CBZ therapy (20 mg/kg), whereas an evident diminution of circulating T3 (ng/dl) and FT3 (pg/ml) was found only in the patient n.5. Three subjects had post-treatment serum TSH (μu/ml) wich rose to hypothyroid levels parallely to the T4 decrease. Serum TBG and T3 U values were not minimally modified by therapy. Since in these cases direct effects of CBZ on thyroid can be excluded and on carrier serum proteins as well,the observed changes in thyroid hormone pattern may be due to accelerated T4 clearance, via stimulation of the liver microsomal system.Similar effects are attributed to phentoin(Ann End 44,63A,1983). |
| Databáze: | OpenAIRE |
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