Transplantable colon tumors as chemotherapy screening models

Autor:	J. A. Double, C. R. Ball
Rok vydání:	2006
Předmět:	Oncology Drug Cancer Research medicine.medical_specialty Chemotherapy business.industry media_common.quotation_subject medicine.medical_treatment Colon tumors Internal medicine medicine Dimethylhydrazine business media_common Colorectal Tumors
Zdroj:	Cancer. 36:2437-2440
ISSN:	1097-0142 0008-543X
DOI:	10.1002/1097-0142(197512)36:6<2437::aid-cncr2820360626>3.0.co;2-b
Popis:	A series of transplantable murine colon tumors have been developed from primary tumors induced by dimethylhydrazine. They are moderately- to well-differentiated adenocarcinomas which retain their histologic appearance and growth characteristics through successive transplant generations. The sensitivity of two tumor lines to 11 standard drugs is reported and some correlation shown with the sensitivity of human colorectal tumors to the same drugs. Therapeutic indices are low and each tumor has an individual pattern of sensitivity. The models have potential as secondary drug screening systems and for investigation of factors affecting drug sensitivity.
Databáze:	OpenAIRE
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