Binding of Organic Acids to Surface Receptors of Lymphocytes as an Immunosuppressive Mechanism in Uremia

Autor:	Yoichiro Kawashima, Takehide Takuma, Nobuhiro Sugino, Yutaro Hayasaka, Kazuo Ota, Paul F. Gulyassy, Tsutomu Sanaka
Rok vydání:	1987
Předmět:	medicine.medical_specialty medicine.medical_treatment Albumin Immunosuppression Plasma protein binding medicine.disease Uremia chemistry.chemical_compound Endocrinology chemistry Biochemistry Internal medicine Detoxification medicine Receptor Mitogenic activity Quinolinic acid
Zdroj:	Advances in Experimental Medicine and Biology ISBN: 9781468454475
DOI:	10.1007/978-1-4684-5445-1_27
Popis:	Some organic acids which inhibit binding of small ligands to plasma, so called protein binding inhibitors (PB-Ix), accumulate in body fluids of patients with renal failure. PB-Ix are believed to bind to sites on the surface of albumin and inhibit its detoxification, transport and reservoir functions1)2)3). They may play a wider toxic role, such as immunosuppression in uremic patients. PB-Ix have been shown to inhibit the mitogenic activity of lymphocytes4).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cf84fd3c60e21f0655dfea1661accece https://doi.org/10.1007/978-1-4684-5445-1_27 Zobrazit plný text záznamu