Studies on anabolic steroids. 10. Synthesis and identification of acidic urinary metabolites of oxymetholone in a human11Part 9 of this paper is in press (itSteroids vol 57, 1992)
| Autor: | Robert Massé, Honggang Bi, George Just |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Pharmacology
Chromatography Anabolism medicine.medical_treatment Metabolite Organic Chemistry Clinical Biochemistry Urine Mass spectrometry Biochemistry Steroid chemistry.chemical_compound Endocrinology chemistry Oral administration Oxymetholone medicine Gas chromatography Molecular Biology medicine.drug |
| Zdroj: | Steroids. 57:453-459 |
| ISSN: | 0039-128X |
| DOI: | 10.1016/0039-128x(92)90100-n |
| Popis: | Two major unconjugated acidic metabolites of oxymetholone (17 beta-hydroxy-2-hydroxymethylene-17 alpha-methyl-5 alpha-androstan-3-one, 1), namely, 17 beta-hydroxy-17 alpha-methyl-2,3-seco-5 alpha-androstane-2,3-dioic acid (2) and 3 alpha,17 beta-dihydroxy-17 alpha-methyl-5 alpha-androstane-2 beta-carboxylic acid (6a), were detected by gas chromatography/mass spectrometry in urine samples collected after oral administration of 1 to a human volunteer. Reference steroid 2 was synthesized and identified. The identification of urinary metabolite 6a was based on the synthesis of its stereoisomers and the isomerization of the methyl ester 6b to its 2-epimer, 3 alpha,17 beta-dihydroxy-17 alpha-methyl-5 alpha-androstane-2 alpha-carboxylic acid methyl ester (9b). The mechanisms accounting for the formation of these acidic metabolites are discussed. |
| Databáze: | OpenAIRE |
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