Zentrale Hämodynamik der Antihypertensiva: Untersuchungen mit Co-Dergocrinmesylat

Autor:	D Welzel, G Weidinger, K Koppenhagen
Rok vydání:	2008
Předmět:	Inotrope Cardiac output medicine.medical_specialty Ejection fraction business.industry Hemodynamics Physical exercise General Medicine Stroke volume medicine.anatomical_structure Blood pressure Internal medicine Cardiology medicine Vascular resistance business
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 109:1064-1068
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2008-1069325
Popis:	The haemodynamic effects of a three-week-treatment with 4-8 mg co-dergocrinmesylate (Hydergin spezial) were investigated in 14 hypertensive patients with a mean age of 58 years and reduced ventricular function (exertional dyspnoea, enlarged cardiac opacity). Blood pressure values at rest and during physical exercise were reduced significantly. Marked cardiac relief was induced manifesting as decrease of enddiastolic and endsystolic volumes and at the same time as an increase of ejection fraction. Cardiac output remained largely constant, lowering of blood pressure was exclusively due to alteration of peripheral total vascular resistance. Cardiac frequency decreased significantly. There was no evidence of negative inotropic effects. Systolic wall tension as the main therapeutic target decreased at rest and during ergometry by 20% and 25%, respectively. Renal perfusion increased slightly, but significantly, in all patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cf802314a6a0cdf4f2051f1d49d4030b https://doi.org/10.1055/s-2008-1069325 Zobrazit plný text záznamu