The polymeric immunoglobulin receptor is present on hepatocytes in human liver

Autor:	J. I. Wyatt, M. Van Schaik, Barbara M. Mullock, J P Luzio, D. G. D. Wight, J H Perez
Rok vydání:	1990
Předmět:	Immunoglobulin A medicine.anatomical_structure Biochemistry Cell culture Secretory component Cell surface receptor Hepatocyte medicine biology.protein Secretion Biology Polymeric immunoglobulin receptor Receptor
Zdroj:	Advances in Mucosal Immunology ISBN: 9789401073233
DOI:	10.1007/978-94-009-1848-1_182
Popis:	It is widely believed (Brandtzaeg, 1985; Delacroix & Vaerman, 1983; Tomana, Kulhavy & Mestecky, 1988; Brown & Kloppel, 1989) that the polymeric IgA receptor (pIgAR) cannot be detected in or on human hepatocytes. In rats and several other species it is accepted that hepatocytes synthesize the pIgAR and use it to transfer polymeric IgA (pIgA) across the cell from blood to bile. At the biliary face of the hepatocyte, the pIgAR is proteolytically cleaved, releasing either secretory IgA (sIgA) when pIgA has been bound or free secretory component (FSC).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cf761c7d970e5db571771652dc6c1776 https://doi.org/10.1007/978-94-009-1848-1_182 Zobrazit plný text záznamu