Amenorrhea as a Prognostic Indicator in Endometriosis Patients Treated with Danazol
| Autor: | L. R. Malinak, G. O. Patton, M. L. Crowder, M. L. Maccato, J. M. Wheeler |
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| Rok vydání: | 1987 |
| Předmět: |
Danazol
medicine.medical_specialty business.industry medicine.medical_treatment Endometriosis medicine.disease Prolactin Steroid Endocrinology Internal medicine medicine Amenorrhea medicine.symptom Receptor business Dose Reduced hormones hormone substitutes and hormone antagonists medicine.drug Hormone |
| DOI: | 10.1159/000414878 |
| Popis: | The LH and FSH levels showed a decreasing tendency during the treatment. There was no significant change in the prolactin and hydroxycortisone values. The estradiol and progesterone significantly fell, although when Danol was withdrawn or the dose reduced there was a striking elevation in the estradiol levels. Based on these results, we suggest that danol, although it was previously thought to have antigonadotroph effects, is acting rather on the steroid receptors or as an inhibitor of the steroid synthesis. At the end of the 6-month danol treatment luteinizing hormonereleasing hormone was given intravenously and caused a significant increase in LH levels which seems to support this hypothesis. |
| Databáze: | OpenAIRE |
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