Systemic Reaction to Human Growth Hormone Treated With Acute Desensitization
| Autor: | Susannah B. Walker, Michael E. Weiss, Diana S. Tattoni |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Allergy Angioedema business.industry medicine.medical_treatment Insulin Hypopituitarism medicine.disease Short stature law.invention Endocrinology law Internal medicine Pediatrics Perinatology and Child Health medicine Recombinant DNA medicine.symptom business Anaphylaxis Desensitization (medicine) |
| Zdroj: | Pediatrics. 90:108-109 |
| ISSN: | 1098-4275 0031-4005 |
| Popis: | Recombinant DNA technology has led to increased production and widespread use of recombinant growth hormone. Systemic allergic reactions to recombinant growth hormone such as urticaria, angioedema, or anaphylaxis have not been described in the literature. We report a patient who developed generalized urticaria from recombinant human growth hormone (Humatrope, Eli Lilly and Company) in whom we successfully desensitized to growth hormone using a protocol modified from an insulin desensitization schedule.1 CASE REPORT A 12-year-old girl with hypopituitarism and short stature had been treated with 2 mg to 5 mg of Humatrope (depending on her weight and responsiveness to treatment) intramuscularly 6 days a week for 3 years without any problems. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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