CHOLESTEROL LOWERING EFFECT OF CHITOSAN NANOPARTICLES USING PARIJOTO FRUITS EXTRACT

Autor:	Rissa Laila Vifta, Fania Putri Luhurningtyas, Mahardika Adhi Candra, Nur Syarohmawati
Rok vydání:	2020
Předmět:	Anti-cholesterol Chemistry Cholesterol lowering Nanoparticle Food science Chitosan nanoparticles
Zdroj:	Journal of Pharmaceutical Sciences and Community. 17:102-111
ISSN:	2527-7146 1693-5683
Popis:	Parijoto (Medinilla speciosa Reinw. ex Blum) fruit is known to have pharmacological activity as cholesterol lowering levels. Its activity needs to be increased with nanoparticle system so that the active substance can bind 100% to the action target. This study aims to determine the formation of nanoparticles from parijoto fruit (NEBP) and activity test as a decrease in cholesterol levels. The formation of nanoparticles used variations of concentration and volume of chitosan and NaTPP. Anti-cholesterol testing is based on the amount of free cholesterol in the sample that reacted with Lieberman-Burchard into complex green compounds. The best formation of NEBP was 0.2% chitosan, 0.1% NaTPP and volume ratio 5:1. The particle size showed an average size of 269.3 nm (10-1000 nm). The result of the percent transmittance and polydispersity index were 99,379 (close to 100%) and 0.378 (PDI
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cf72000da83aa701e40e425bf59058c5 https://doi.org/10.24071/jpsc.002017 Zobrazit plný text záznamu