Synthesis, DNA binding and docking studies of copper(II) complexes containing modified phenanthroline ligands

Autor:	Sankaralingam Arunachalam, R. Vijay Solomon, Jagadeesan Lakshmipraba, Ponnambalam Venuvanalingam
Rok vydání:	2015
Předmět:	Circular dichroism Phenanthroline Intercalation (chemistry) Phenazine chemistry.chemical_element Copper Square pyramidal molecular geometry chemistry.chemical_compound Crystallography chemistry Docking (molecular) Materials Chemistry Physical and Theoretical Chemistry DNA
Zdroj:	Journal of Coordination Chemistry. 68:1374-1386
ISSN:	1029-0389 0095-8972
DOI:	10.1080/00958972.2015.1014349
Popis:	Copper(II) complexes, [Cu(Hsal)(L)(ClO4)] (where Hsal = salicylaldehyde, 1: L = dpqC = dipyrido[3,2-a:2′,3′-c](6,7,8,9-tetrahydro)phenazine and 2: L = dppz = dipyrido[3,2-a:2′,3′-c]phenazine), were synthesized and characterized using elemental analysis and spectroscopic methods. Single-crystal XRD on 1 confirms the presence of square pyramidal geometry around Cu(II). DNA interaction studies were performed for both the complexes using UV–visible, fluorescence and circular dichroism spectroscopic techniques, and viscosity. These complexes bind with DNA through partial intercalation. Molecular docking studies confirm our experimental findings of mode of binding of our complexes with DNA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cf6573d209d8ce4d9a75de3e995850d5 https://doi.org/10.1080/00958972.2015.1014349 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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