ChemInform Abstract: Quinolone Derivatives: Synthesis and Binding Evaluation on Cholecystokinin Receptors

Autor:	Marina Zacchigna, Antonio Varnavas, E. Boccù, E. Luxich, F. Pichierri, Lucia Lassiani
Rok vydání:	2010
Předmět:	Biochemistry Chemistry medicine.drug_class Stereochemistry digestive oral and skin physiology medicine General Medicine Receptor Quinolone digestive system Cholecystokinin receptor Affinities hormones hormone substitutes and hormone antagonists
Zdroj:	ChemInform. 27
ISSN:	0931-7597
DOI:	10.1002/chin.199642162
Popis:	A series of 2-methyl-3-amino-4(H)-quinazolinone and of 2-phenyl-3-amino-4(H)-quinazolinone derivatives were synthesized and examined for their CCK receptor affinities. These compounds displayed micromolar affinities for CCK-B rather than CCK-A receptor and the obtained results confirm that the 4(3H)-quinazolinone nucleous represent a useful template for the development of selective CCK-B receptor ligands.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cf600b65903bb9b4ab0890e651d99f03 https://doi.org/10.1002/chin.199642162 Zobrazit plný text záznamu Plný text