| Autor: |
Jintanaporn Wattanathorn, Panakaporn Wannanon, Wathita Phachonpai, Terdthai Tong-Un, Supaporn Muchimapura |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
American Journal of Agricultural and Biological Sciences. 7:271-277 |
| ISSN: |
1557-4989 |
| DOI: |
10.3844/ajabssp.2012.271.277 |
| Popis: |
Public concern on mental health has noticeably incr eased given the high prevalence of neuropsychiatric disorders especially anxiety and depression. Most o f the drugs for these conditions used nowadays have adverse side effects so the need for newer, better- tolerated and more efficacious treatments is remain ing high. Growing attention is being paid to traditiona l herbal medicines. Stephania venosa Spreng ( S. venosa ; SV) is a Thai traditional herb which has been used for cancer treatment as well as an aphrodisiac. In addition, accumulating lines of evidence reported t hat the ethanol extract of SV exhibited an antioxid ant and exerted acetylcholinesterase inhibitory. However, t he in vivo neurophamacological activities of this plant have never been studied. The aim of this study was to examine the neurophamacological effects of a cru de extract of SV introduced orally at various doses ra nging from 5, 10 and 20 mg kg -1 BW once daily for a period of 2 weeks. The anxiolytic and anti-depressi on like activities were determined after single administration, 1 and 2 weeks of treatment using el evated plus maze and forced swimming test respectively. Only SV 20 mg kg -1 treated rats exhibited a significant anxiolytic ef fect at all treatment duration. Unfortunately, this substance failed to show anti-depression like activity. Our findings provide a potential of the S V consumption might be used as a novel therapeutic strategy for t he anti-anxiety disorder. However, further investig ations about possible active ingredients and the precise underly ing mechanisms are still necessary. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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