Successful Central Nervous System Prophylaxis Without Radiotherapy in Childhood Acute Lymphoblastic Leukemia (ALL); Israel National Studies (INS 1984, 1989)

Autor:	L. Jaber, Aghai, Dalia Sthoeger, Y. Yaniv, A. Hazani, A. Abromov, R. Zaizov, Y. Horovitz, Y. Neuman, Chaim Kaplinsky, M. Mandel, B. Stark, N. Ramu, G. Chividalli, Yoav Barak, G. Rechavi, Y. Burstein, R. Sharon, G. Kende, Dina Attias, Y. Goshen, I. J. Cohen, H. Tamari, A. Balin
Rok vydání:	1994
Předmět:	Pediatrics medicine.medical_specialty business.industry medicine.medical_treatment Central nervous system Sequela medicine.disease Occult Radiation therapy Leukemia medicine.anatomical_structure Cranial Irradiation medicine Methotrexate business Childhood Acute Lymphoblastic Leukemia medicine.drug
Zdroj:	Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ISBN: 9783642783524
DOI:	10.1007/978-3-642-78350-0_63
Popis:	Adequate early prophylactic treatment for occult central-nervous-system (CNS) leukemia is one of the key elements for successful treatment in childhood acute lymphoblastic leukemia (ALL). The classical treatment of cranial irradiation 2400cGY and IT methotrexate (MTX) which was very efficient in reducing overall CNS relapse rate to 10%, and to increase cure rate [1-3J, was found to be associated with severe late sequela of secondary neoplasms (brain tumors) and significant neuro-psychological damage [4-6].
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cf446d2804b7a6e568602f2af65a0ff2 https://doi.org/10.1007/978-3-642-78350-0_63 Zobrazit plný text záznamu