Fucoidans as a platform for new anticoagulant drugs discovery

Autor:	M. E. Preobrazhenskaya, Nikolay E. Nifantiev, Anatolii I. Usov, Maria I. Bilan, Guangli Yu, Saurabh Saran, Chunxia Li, Nadezhda V. Krukovskaya, N. A. Ushakova, Rajendra Kumar Saxena, Mikhail Kiselevskiy, Nadezhda E. Ustyuzhanina, Eugenia A. Tsvetkova, Natalia A. Anisimova, Vadim B. Krylov
Rok vydání:	2014
Předmět:	chemistry.chemical_compound Thrombin Chemistry Drug discovery medicine.drug_class Fucoidan General Chemical Engineering Hemostasis Anticoagulant medicine General Chemistry Pharmacology medicine.drug
Zdroj:	Pure and Applied Chemistry. 86:1365-1375
ISSN:	1365-3075 0033-4545
DOI:	10.1515/pac-2014-0404
Popis:	Anionic fucose-containing polysaccharides (fucoidans of brown seaweeds, sulfated fucans and fucosylated chondroitin sulfates of invertebrates) are attracting a rapidly growing research interest due to different types of their biological activity discovered in recent years. In particular, algal fucoidans are characterized by large structural variations depending on the species used for their isolation and by the lack of structural regularity due to random distribution of both carbohydrate and non-carbohydrate substituents along the polymer chains. These features make it difficult to find distinct correlations between structural elements and biological properties of polysaccharides. Nevertheless, there is expectation that systematic structural and biochemical studies of fucoidans will form a basis for the development of new drugs. Herewith we summarize our recent results on the influence of fucoidan structure on blood coagulation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cf4353ab947eafd5c326465b152417fe https://doi.org/10.1515/pac-2014-0404 Zobrazit plný text záznamu Plný text ve formátu PDF