Multifunctional, Biocompatible, Non-peptidic Hydrogels: from Water Purification to Drug Delivery
| Autor: | Clare L. Higgins, Benjamin C. Baker, Barnaby W. Greenland, Gary C. Stevens, Francesca Greco, Divyashree Ravishankar, Wayne Hayes, Howard M. Colquhoun |
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| Rok vydání: | 2016 |
| Předmět: |
Drug
Materials science Biocompatibility media_common.quotation_subject Portable water purification Good control 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Biocompatible material 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Drug delivery Self-healing hydrogels Urea Organic chemistry 0210 nano-technology media_common |
| Zdroj: | ChemistrySelect. 1:1641-1649 |
| ISSN: | 2365-6549 |
| DOI: | 10.1002/slct.201600249 |
| Popis: | A novel series of low molecular weight non-peptidic, biocompatible super-hydrogelators with both water purification and drug delivery properties have been developed. Linking the bis aromatic urea groups responsible for gelation together to form bi- and tri-armed gelators, affords good control over gelation and water purification properties. The use of the gels as effective drug scavengers and delivery systems has been demonstrated with dye substrates, via pH inversion, as monitored by UV-vis spectroscopy. Finally, the systems′ abilities as both drug scavenging and delivery systems have been demonstrated with the clinically-approved drugs chlorpromazine and doxorubicin, respectively. |
| Databáze: | OpenAIRE |
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