Cytology and colchicine sensitivity of viable cells from lymph nodes with malignant lymphoma

Autor:	Stefano S. Stefani, Zelma Molnar, Robert Schrek
Rok vydání:	1978
Předmět:	Cancer Research Pathology medicine.medical_specialty business.industry Malignancy medicine.disease Lymphoma Malignant lymphoma Oncology Cytology medicine False positive paradox COLCHICINE SENSITIVITY Positive test Lymph business
Zdroj:	Cancer. 41:1845-1856
ISSN:	1097-0142 0008-543X
DOI:	10.1002/1097-0142(197805)41:5<1845::aid-cncr2820410528>3.0.co;2-2
Popis:	Viable cell suspensions were prepared from 31 nodes diagnosed non-Hodgkin's malignant lymphoma, and from 30 non-malignant nodes. The cells were examined and counted by phase contrast microscopy. The suspensions were characterized by the percentage of large cells and by a colchicine-sensitivity index. The finding of more than 6% large cells or the finding of a sensitivity index of more than 30% was considered a positive test for a malignant lymphoma. According to these criteria there were 2 false positives in 30 reactive nodes and one false negative in 31 malignant nodes. Findings on 3 nodes diagnosed angioimmunoblastic lymphadenopathy suggested malignancy. The colchicinesensitivity index of blood lymphocytes seemed useful for monitoring lymphoma patients for leukemic involvement.
Databáze:	OpenAIRE
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