The synthesis of novel mimics of the sialyl Lewis X determinant

Autor:	Nigel M. Allanson, Alan Hornsby Davidson, Christopher David Floyd, Fionna M. Martin
Rok vydání:	1994
Předmět:	chemistry.chemical_classification Ketone Nucleophilic addition Stereochemistry Organic Chemistry Disaccharide Catalysis Fucose Sialic acid carbohydrates (lipids) Inorganic Chemistry chemistry.chemical_compound Sialyl-Lewis X chemistry Lewis acids and bases Physical and Theoretical Chemistry Linker
Zdroj:	Tetrahedron: Asymmetry. 5:2061-2076
ISSN:	0957-4166
DOI:	10.1016/s0957-4166(00)86284-9
Popis:	Disaccharide mimics of the sialyl Lewis X (sLe x ) ligands have been prepared as potential antagonists of binding to the lectin domains of the E-selectin adhesion molecule. Versatile derivatives of sialic acid provide an entry to a series of simplified linker groups supporting the fucose and sialyl residues. The stereoselectivity of nucleophilic addition to the fucosyl ketone derivative 7 is determined by the conditions employed: basic and Lewis acid conditions give opposite results.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cf33e238f6628b13dfcc5e67f9580057 https://doi.org/10.1016/s0957-4166(00)86284-9 Zobrazit plný text záznamu