Radio protective effect of black mulberry extract on radiation-induced damage in bone marrow cells and liver in the rat
| Autor: | Mansour Homayoun, Mohammad Soukhtanloo, Reza Ghasemnezhad Targhi, Masoumeh Seghatoleslam, Shokouhozaman Soleymanifard, Somaieh Mansouri |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Radiation Antioxidant biology Chemistry medicine.medical_treatment Malondialdehyde medicine.disease_cause Molecular biology Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Catalase 030220 oncology & carcinogenesis biology.protein medicine Bone marrow Micronucleus Genotoxicity Oxidative stress |
| Zdroj: | Radiation Physics and Chemistry. 130:297-302 |
| ISSN: | 0969-806X |
| DOI: | 10.1016/j.radphyschem.2016.08.030 |
| Popis: | Ionizing radiation by producing free radicals induces tissue oxidative stress and has clastogenic and cytotoxic effects. The radio protective effect of black mulberry extract (BME) has been investigated on liver tissue and bone marrow cells in the rat. Intraperitoneal (ip) administration of 200 mg/kg BME three days before and three days after 3 Gy and 6 Gy gamma irradiation significantly reduced the frequencies of micro nucleated polychromatic erythrocytes (MnPCEs) and micro nucleated norm chromatic erythrocyte (MnNCEs) and increased PCE/PCE+NCE ratio in rat bone marrow compared to the non-treated irradiated groups. Moreover, this concentration of BME extract decreased the level of malondialdehyde (MDA) and superoxide dismutase (SOD), as well as enhanced the total thiol content and catalase activity in rat's liver compared to the non-treated irradiated groups. It seems that BME extract with antioxidant activity reduced the genotoxicity and cytotoxicity induced by gamma irradiation in bone marrow cells and liver in the rat. |
| Databáze: | OpenAIRE |
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