Prospective evaluation of a two-week course of intravenous antibiotics in intravenous drug addicts with infective endocarditis
Autor: | M de Cueto, A. Vergara, Manuel Torres-Tortosa, Antonio Sánchez-Porto, J Canueto, E. Perez-Guzman, M. González-Serrano |
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Rok vydání: | 1994 |
Předmět: |
Microbiology (medical)
medicine.medical_specialty Respiratory distress medicine.drug_class business.industry Antibiotics General Medicine medicine.disease Surgery Infectious Diseases Pharmacotherapy Cloxacillin Amikacin Infective endocarditis Internal medicine medicine Endocarditis Prospective cohort study business medicine.drug |
Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 13:559-564 |
ISSN: | 1435-4373 0934-9723 |
DOI: | 10.1007/bf01971306 |
Popis: | In a prospective study, a two-week course of antibiotics (cloxacillin 2 g/4 h plus amikacin 7.5 mg/kg/12 h) was evaluated in the therapy of right-sided infective endocarditis in intravenous drug users (IVDU). All IVDU admitted to hospital during the study period who fulfilled the strict criteria for diagnosis of infective endocarditis were analysed. A subgroup of patients with right-sided endocarditis caused byStaphylococcus aureus who had a good prognosis were selected as being eligible for the two-week course of treatment. In a total of 139 episodes of infective endocarditis in IVDU, 72 (51.8 %) cases were eligible for the two-week treatment. Of this group, 67 were cured, 4 needed prolongation of treatment to cure the infection and 1 died in hospital of respiratory distress syndrome on day 10 of treatment. In patients not eligible for the two-week treatment, the mortality was higher (24.2 % versus 0.7 %; p=0.00015). Drug toxicity in the treated group was low. It can be concluded that administration of cloxacillin and amikacin parenterally for 14 consecutive days was successful in the therapy of right-sided endocarditis in IVDU. |
Databáze: | OpenAIRE |
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