PCR-RAFT: rapid high throughput oxygen tolerant RAFT polymer synthesis in a biology laboratory
| Autor: | Carlos Sanchez-Cano, Sébastien Perrier, Joji Tanaka, Daniel W. Lester, Pratik Gurnani, Christopher D. Stubbs, Thomas Floyd |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Molar mass Polymers and Plastics Organic Chemistry Bioengineering Nanotechnology 02 engineering and technology Polymer Raft 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound Monomer Polymerization chemistry Drug delivery 0210 nano-technology Throughput (business) Macromolecule |
| Zdroj: | Polymer Chemistry. 11:1230-1236 |
| ISSN: | 1759-9962 1759-9954 |
| DOI: | 10.1039/c9py01521c |
| Popis: | Some of the main applications for synthetic polymers are found within the medical field (drug delivery, diagnostics, medical imaging). However, preparation of these macromolecules has been limited to those with access to chemistry facilities, potentially delaying biological evaluation. In this work, we aim to address this issue by utilising equipment typically found within a biological lab to establish a protocol for the preparation of well-defined macromolecules via RAFT polymerisation. By exploiting thermocycler technology, libraries of homopolymers, block- and statistical-copolymers were prepared in under 5 minutes per heating cycle using acrylamide monomers with ultrafast RAFT polymerisation. All the polymers prepared had excellent molar mass control and could be generated in under 15 min. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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