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Ryanoids are a family of natural compounds that are well known for their biological activity in plants as pesticides, and in mammalian muscle tissue as calcium permeability modulators. As part of an investigation of the structure-activity relationship of ryanoids, the crystal structures of five new compounds were elucidated: 2-deoxy-3-epiryanodol (C 20 H 32 O 7 ), 3-deoxyryanodol hydrate (cinnzeylanol; 2C 20 H 32 O 7 .5.15H 2 O), 2-deoxyryanodol hydrate (2C 20 H 32 O 7 .2.5H 2 O), 2,3-dideoxyryanodol hydrate (C 20 H 32 O 6 .1.5H 2 O) and 3a,4a,8,8b-tetrahydroxy-2-isopropyl-4,7-dimethyl-1-methylene-1,3a,4,4a,5,6,7,8,8a,8b-decahydro-8a,4-(epoxyethano)-benzo[a]pentalen-10-one (C 20 H 28 O 6 ). The numerous hydroxyl groups on the molecules modulate the crystal packing. Successive modifications on ring A induce major changes in the hydrogen-bond scheme, from a three-dimensional (3D) to a two-dimensional (2D) network. |
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