Autor:	J.S. Kelly
Rok vydání:	2007
Předmět:	chemistry.chemical_classification Programmed cell death Necrosis Ischemia Glutamate receptor Neurotoxicity Pharmacology Biology medicine.disease Amino acid chemistry Apoptosis medicine Excitatory postsynaptic potential medicine.symptom Neuroscience
DOI:	10.1016/b978-012373947-6.00065-9
Popis:	Calcium-dependent neurotoxicity plays a key role in stroke and head injury. Ischemia and/or anoxia cause excessive release of excitatory amino acids. Following glutamate receptors' overactivity, a rise in [Ca2+]i triggers neuronal and glial cell death by necrosis and/or apoptosis. Therapeutically, excitatory amino acid receptor blockade has proved to be a failure.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cf226cf7184751b74e76b6561ca76aa1 https://doi.org/10.1016/b978-012373947-6.00065-9 Zobrazit plný text záznamu