The influence of amorphous macrodiol, diisocyanate type and l-ascorbic acid modifier on chemical structure, morphology and degradation behavior of polyurethanes for tissue scaffolds fabrication
| Autor: | Justyna Kucińska-Lipka, Helena Janik, Iga Gubańska |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Polymers and Plastics Chemical structure 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Ascorbic acid 01 natural sciences Isocyanate 0104 chemical sciences Dibutyltin dilaurate Amorphous solid Catalysis chemistry.chemical_compound chemistry Chemical engineering Mechanics of Materials Adipate Materials Chemistry Fourier transform infrared spectroscopy 0210 nano-technology |
| Zdroj: | Polymer Degradation and Stability. 163:52-67 |
| ISSN: | 0141-3910 |
| Popis: | Studies described in this work were related to the bulk synthesis and characterization of polyurethanes (PURs) obtained with the use of cyclic 4,4′-methylene bis(cyclohexyl isocyanate) (HMDI) or linear 1,6-hexamethylene diisocyanate (HDI), amorphous α,ω-dihydroxy(ethylene-butylene adipate) macrodiol (PEBA), 1,4-butandiol (BDO) chain extender and dibutyltin dilaurate (DBTDL) catalyst. Obtained PURs were modified with l -ascorbic acid (AA). Raw materials and modifier improving biocompatybility were carefully selected due to the planned use of obtained PURs as a tissue scaffold fabrication material. Performed chemical structure studies (FTIR, ATR-IR, 2D NMR), morphology observations (SEM, TEM and AFM) and characterization of degradation profile revealed that PURs obtained by using HDI were representing a significantly better characteristic than those obtained by using HMDI. Thus, the HDI-based PURs were suggested for further development as a materials useful for tissue scaffolds fabrication in the field of tissue engineering. |
| Databáze: | OpenAIRE |
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