SEROLOGIC RESPONSES TO HEPATITIS C VIRUS IN SOLID ORGAN TRANSPLANT RECIPIENTS1
| Autor: | J. M. Fenton, Jutta K. Preiksaitis, N. I. Burton, S. M. Cockfield, L. W.-L. Chui |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Transplantation
education.field_of_study Blood transfusion business.industry medicine.medical_treatment Hepatitis C virus Population virus diseases Hepatitis C medicine.disease medicine.disease_cause digestive system diseases Serology Immunology medicine Viral disease Seroconversion business education |
| Zdroj: | Transplantation. 64:1775-1780 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/00007890-199712270-00026 |
| Popis: | Background. Hepatitis C (HCV) infection is known to have been transmitted by both blood transfusion and donor organs. We sought to determine the historical incidence of donor- and transfusion-acquired HCV infection in kidney transplant (RTx) and heart transplant (HTx) recipients at our center and to study the kinetics of seroconversion to HCV. Methods. A bank of sera collected from organ donors (388 RTx and 88 HTx) who received allografts between January 1984 and April 1992 was screened for anti-HCV using a third generation enzyme immunoassay. Recipient sera collected before transplant (preTx), at 1 year after transplant, and at last follow-up were tested. Fresh follow-up sera on all surviving anti-HCV-positive (+) RTx and HTx, all anti-HCV-negative (-) HTx, and a subset of 85 anti-HCV - RTx were assayed for HCV RNA using an reverse transcriptase-polymerase chain reaction assay. Results. Twenty-four of 388 RTx (6.2%) and 2 of 88 HTx (2.3%) were anti-HCV + preTx. Eight of 218 (3.7%) organ donors were anti-HCV + . Six of the seven (85.7%) anti-HCV + donors with adequate recipient follow-up transmitted HCV infection to one or more recipients. Nineteen of 313 RTx (6.1%) and 8 of 72 HTx (11.1%) with follow-up |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|