| Autor: |
Juergen Swienty-Busch, Jeff Labadie, Peter Wright, Lanchi Vo, Young K. Yun |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
Journal of the Association for Laboratory Automation. 6:56-58 |
| ISSN: |
1535-5535 |
| DOI: |
10.1016/s1535-5535(04)00145-5 |
| Popis: |
High throughput parallel organic synthesis is now a common practice in discovery chemistry research. Argonaut's modular reaction cassette technology is aimed at parallel synthesis of focused small molecule libraries. The Trident™ automated platform has been designed to perform high throughput organic synthesis using this modular reaction cassette under truly inert conditions and in a robust, reproducible manner. This enables one to generate high quality libraries of small molecules and to access chemistry not normally amenable to automation.Recently we have introduced a Sample Processing Station (SPS), which enhances the upstream and downstream sample handling capabilities of the Trident™ platform. Enhanced software capabilities also provide the Trident™ synthesizer with powerful reaction development and optimization capabilities. Application of this technology in the synthesis of a small library of 1,2-diarylbenzimidazoles using solution-phase chemistry is presented. A number of product purification and ... |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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