Perinatal Transmission of Hepatitis C Virus from Human Immunodeficiency Virus Type 1‐Infected Mothers

Autor:	David L. Thomas, Thomas C. Quinn, Ronald C. Hershow, Lynne M. Mofenson, Infants Transmission Study, F. Blaine Hollinger, Women, Clemente Diaz, Laura E. Riley, Sheldon Landesman, Katherine A. Riester, Hope Babette Tang, Stephen A. Villano, Katherine Davenny
Rok vydání:	1998
Předmět:	biology Hepatitis C virus Hepacivirus virus diseases medicine.disease_cause biology.organism_classification Virology digestive system diseases Virus Flaviviridae Infectious Diseases Immunology Lentivirus medicine Immunology and Allergy Viral disease Sida Viral load
Zdroj:	The Journal of Infectious Diseases. 177:1480-1488
ISSN:	1537-6613 0022-1899
DOI:	10.1086/515315
Popis:	Antepartum plasma hepatitis C virus (HCV) RNA was quantified in 155 mothers coinfected with HCV and human immunodeficiency virus type 1 (HIV-1), and HCV RNA was serially assessed in their infants. Of 155 singleton infants born to HCV antibody-positive mothers, 13 (8.4%) were HCV infected. The risk of HCV infection was 3.2-fold greater in HIV-1-infected infants compared with HIV-1-uninfected infants (17.1% of 41 vs. 5.4% of 112, P = .04). The median concentration of plasma HCV RNA was higher among the 13 mothers with HCV-infected infants (2.0 x 10(6) copies/mL) than among the 142 mothers with HCV-negative infants (3.5 x 10(5) copies/mL; P < .001), and there were no instances of HCV transmission from 40 mothers with HCV RNA concentrations of < 10(5) copies/mL. Women dually infected with HIV-1 and HCV but with little or no detectable HCV RNA should be reassured that the risk of perinatal transmission of HCV is exceedingly low.
Databáze:	OpenAIRE
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